PRESS RELEASE
Human neutrophil defensins (alpha-defensins) belong together with the beta-defensins to the multi-membrane families of cationic trisulfide-containing (microbicidal) peptides. They exert their microbicidal activity by permeating the membrane involving the formation of voltage regulated ion channels.Azurophilic granules of neutrophils contain Human Neutrophil Defensins (HNP) 2-4. HNP 1-3 are highly homologous. Activation of neutrophils leads to rapid release of HNP. HNP can be measured in plasma and other body fluids during infection and inflammation. In normal plasma very low levels of HNP are present. Activation of polymorphonuclear leukocytes (PMN) in plasma as occurs during clotting of blood leads to a rapid release of HNP. The assay is useful for detection of HNP 1-3 in tissue culture media, plasma and other body fluids.
Cell Sciences offers HyCult Biotechnology HNP 1-3 products as follows:
Catalog No: HK317 , HNP 1-3 ELISA kit, 192 determinations
Catalog No: HM2058 , HNP 1-3, clone D21 mAb, 100 ug
Catalog No: HM2059 , HNP 1-3, clone D21, biotinylated mAb, 50 ug
Catalog No: HM4008, Rabbit NP-5, clone R3 mAb, 100 ug
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