CD14 and LBP Products

CD14 and LBP: ELISA kits, recombinant proteins, monoclonal and polyclonal antibodies

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CD14:
CD14 is the 53-kD glycophosphatidylinositol (GPI)-linked glycoprotein and functions as high affinity endotoxin (LPS) receptor on the surface of monocytes, macrophages and granulocytes as well as brain cells. Together with TLR4 and a lymphocytic antigen (MD2) CD14 is the lipopolysaccharide (LPS)-Receptor and mediates innate immune response to bacterial lipoproteins. In the presence of LPS, CD14-expression can be amplified by TNF-alpha and IL-1 beta. CD14 is present in a soluble form in human serum, urine and other body fluids which is directly secreted or derived from protease-dependent shedding of the membrane bound molecule. Soluble CD14 (sCD14) competes with membrane bound CD14 (mCD14) for LPS binding and is able to neutralize LPS-induced responses in vitro and in vivo and mediates the LPS-induced activation of non-CD14-expressing endothelial, epithelial and smooth-muscle cells.

CD14 Reagents

CKH114  Human sCD14 ELISA Kit

CKM034  Mouse sCD14 ELISA Kit

CDM150  Mouse Anti-Human CD14 Clone B-A8 Azide Free mAb

CMC000  Mouse Anti-Human CD14 Clone biG 10 mAb

CMC001  Mouse Anti-Human CD14 Clone biG 13 multispecies mAb

CMC005  Mouse Anti-Mouse CD14 Clone biG 53 mAb

CRCC01  Recombinant Human CD14

CRCC03  Recombinant Mouse CD14


 

LBP:
LBP (Lipopolysaccharide binding protein) is a 58-kD acute phase glycoprotein, binds to the lipid A portion of Lipopolysaccharide (LPS) with high affinity and catalyzed the CD14 and TLR4 dependent cellular activation by LPS. LBP interacted with CD14, TLR2, TLR4 und the co-receptor MD-2. LBP is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain LPS on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), LBP binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses.

LBP Reagents

CKH113  Human LBP Multispecies Reactive ELISA Kit

CKM043  Mouse LBP ELISA Kit

CML002  Mouse Anti-Human LBP Clone biG 42 mAb†

CML003  Mouse Anti-Human LBP Clone biG 48 mAb†

CML004  Mouse Anti-Human LBP Clone biG 412 mAb*

CML007  Mouse Anti-Human LBP Clone biG 43 mAb†

CPC402A  Rabbit Anti-Human LBP pAb

CML001  Mouse Anti-Mouse LBP Clone biG 33 mAb*

CML005  Mouse Anti-Mouse LBP Clone biG 35 mAb†

CPC105  Rabbit Anti-Mouse LBP pAb

CRL701  Recombinant Human LBP

CRL700  Recombinant Mouse LBP

* Inhibits binding to CD14        † Does not inhibit binding to CD14