Products for Cell and Tissue Culture

LRM001

Human LR3 IGF1
Human LR3 Insulin-like Growth Factor 1 (IGF1) is an 83 amino acid analog of human IGF1 comprising the complete human IGF1 sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Recombinant LR3 IGF1 has been developed specifically for supplementation of mammalian cell culture to support the survival and proliferation of cells. It is engineered to have a higher biological potency than native IGF1 or IGF2 and has several advantages over recombinant insulin, potency being among them. Published research has shown that supplementation of cell cultures with LR3 IGF1 at a much lower concentration results in equivalent or better productivity than supplementation with standard concentrations of insulin. LR3 IGF1 is better able to stimulate the Type I IGF Receptor and thus induce a higher level of activation of intracellular signaling molecules which are responsible for promoting cell survival by inhibition of apoptosis. A new formulation of this analog of IGF1 is lyophilized from a solution in PBS, allowing it to be directly dissolved in water or media.

LRU100 Recombinant Human LR3 IGF1 100 µg 
LRM001 Recombinant Human LR3 IGF1 1.0 mg 
LRM010 Recombinant Human LR3 IGF1 10 mg

Human Erythropoietin
Erythropoietin (EPO) is a glycoprotein hormone that controls red blood cell production. It is a cytokine for erythrocyte precursors in the bone marrow. It is produced by the peritubular capillary endothelial cells in the kidney, and is the hormone that regulates red blood cell production. Recombinant Human Erythropoietin (EPO) is a glycosylated polypeptide chain containing 165 amino acids. It is a recombinant protein produced in mammalian cells for use in cell and tissue culture applications.

CRE600A Recombinant Human EPO 500 IU 
CRE600B Recombinant Human EPO 2000 IU 
CRE600C Recombinant Human EPO 150k IU

Bulk quantities of these products are available, please inquire.