Products for the Study of Plasmin Activation

These research reagents are useful in the investigation of plasmin activation. They include PAI-1, tPA, uPA, uPAR, Vitronectin and related proteins and ELISA kits. Plasminogen Activator Inhibitor 1 (PAI-1) plays a key role in fibrinolysis through its regulation of Tissue-type (tPA) and Urokinase-type Plasminogen Activators (uPA). Plasminogen is the inactive zymogen of plasmin, the protease responsible for degrading fibrin. The intricacies of the PAI-1-Plasminogen Activator-Plasmin system and its regulation are being investigated in renal and cardiovascular disease, in addition to inflammation, angiogenesis, and cancer.

In order to facilitate the study of PAI-1, the protein is expressed in E.coli and insect cells producing unmodified and glycosylated forms. A stable mutant form is also available, which contains four mutations that cooperate to increase the half-life from a few hours to over 140 hours (Catalog No. CRP180B). This increased stability is ideal for tissue culture experiments, as well as in vivo animal studies where extended incubations are required. In addition to a full line of recombinant products, Cell Sciences also offers purified native PAI-1, antibodies against PAI-1, and ELISA Kits to detect active and total PAI-1 in a variety of biological fluids from human, mouse, and rat. Human ELISA Kits able to detect PAI-1 in complex with either tPA or uPA are also available.

PAI-1: Plasminogen Activator Inhibitor 1

Cat. No. Description Quantity Price
 CRP173B Recombinant Human PAI-1 0.5 mg $970
 CRP180B Recombinant Human PAI-1, Stable Mutant Form 0.5 mg $970
 CRP175B Recombinant Human PAI-1, Glycosylated 0.5 mg $1,295
 CSI19809A Human PAI-1 Activity ELISA Kit 1 x 96 tests $665
 CSI19810A Human PAI-1 / tPA Complex ELISA Kit 1 x 96 tests $665
 CSI19811A Human PAI-1 / uPA Complex ELISA Kit 1 x 96 tests $665
 CSI19891A Mouse PAI-1 Activity ELISA Kit 1 x 96 tests $665
 CSI19892A Mouse PAI-1 Total ELISA Kit 1 x 96 tests $665
 CSI19918A Rat PAI-1 Activity ELISA Kit 1 x 96 tests $665
 CSI19919A Rat PAI-1 Total ELISA Kit 1 x 96 tests $665

tPA: Tissue Plasminogen Activator

Cat. No. Description Quantity Price
 CRT170B Recombinant Human tPA Active 100 µg $300
 CRT174B Recombinant Human tPA Inactive 100 µg $460
 CRT180B Recombinant Mouse tPA Inactive Non-Cleavable 100 µg $460
 CRT177B Recombinant Mouse tPA 100 µg $460

uPA: Urokinase Plasminogen Activator

Cat. No. Description Quantity Price
 CRU111B Recombinant Human HMW-uPA 100 µg $320
 CRU122A Recombinant Mouse uPA N-terminal fragment 50 µg $450

uPAR: Urokinase Plasminogen Activator Receptor

Cat. No. Description Quantity Price
 CSI20008A Recombinant Mouse Soluble uPAR 100 µg $790

VTN: Vitronectin

Cat. No. Description Quantity Price
 CRV123B Native Human Monomeric Vitronectin 0.5 mg $1,200
 CRV124B Native Human Multimeric Vitronectin 100 µg $320
 CRV126B Native Human Multimeric Vitronectin, Biotinylated 100 µg $480

Related Products

Cat. No. Description Quantity Price
 CRA158B Native Human Alpha-2-Antiplasmin 1.0 mg $600
 CRG128B Native Human Glu Plasminogen 1.0 mg $250
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