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  • Products for the Study of Plasmin Activation

    These research reagents are useful in the investigation of plasmin activation. They include PAI-1, tPA, uPA, uPAR, Vitronectin and related proteins and ELISA kits. Plasminogen Activator Inhibitor 1 (PAI-1) plays a key role in fibrinolysis through its regulation of Tissue-type (tPA) and Urokinase-type Plasminogen Activators (uPA). Plasminogen is the inactive zymogen of plasmin, the protease responsible for degrading fibrin. The intricacies of the PAI-1-Plasminogen Activator-Plasmin system and its regulation are being investigated in renal and cardiovascular disease, in addition to inflammation, angiogenesis, and cancer.

    In order to facilitate the study of PAI-1, the protein is expressed in E.coli and insect cells producing unmodified and glycosylated forms. A stable mutant form is also available, which contains four mutations that cooperate to increase the half-life from a few hours to over 140 hours (Catalog No. CRP180B). This increased stability is ideal for tissue culture experiments, as well as in vivo animal studies where extended incubations are required. In addition to a full line of recombinant products, Cell Sciences also offers purified native PAI-1, antibodies against PAI-1, and ELISA Kits to detect active and total PAI-1 in a variety of biological fluids from human, mouse, and rat. Human ELISA Kits able to detect PAI-1 in complex with either tPA or uPA are also available.

    PAI-1: Plasminogen Activator Inhibitor 1

    Cat. No. Description Quantity Price
     CRP173B Recombinant Human PAI-1 0.5 mg $970
     CRP180B Recombinant Human PAI-1, Stable Mutant Form 0.5 mg $970
     CRP175B Recombinant Human PAI-1, Glycosylated 0.5 mg $1,295
     CSI19809A Human PAI-1 Activity ELISA Kit 1 x 96 tests $665
     CSI19810A Human PAI-1 / tPA Complex ELISA Kit 1 x 96 tests $665
     CSI19811A Human PAI-1 / uPA Complex ELISA Kit 1 x 96 tests $665
     CSI19891A Mouse PAI-1 Activity ELISA Kit 1 x 96 tests $665
     CSI19892A Mouse PAI-1 Total ELISA Kit 1 x 96 tests $665
     CSI19918A Rat PAI-1 Activity ELISA Kit 1 x 96 tests $665
     CSI19919A Rat PAI-1 Total ELISA Kit 1 x 96 tests $665

    tPA: Tissue Plasminogen Activator

    Cat. No. Description Quantity Price
     CRT170B Recombinant Human tPA Active 100 µg $300
     CRT174B Recombinant Human tPA Inactive 100 µg $460
     CRT180B Recombinant Mouse tPA Inactive Non-Cleavable 100 µg $460
     CRT177B Recombinant Mouse tPA 100 µg $460

    uPA: Urokinase Plasminogen Activator

    Cat. No. Description Quantity Price
     CRU111B Recombinant Human HMW-uPA 100 µg $320
     CRU122A Recombinant Mouse uPA N-terminal fragment 50 µg $450

    uPAR: Urokinase Plasminogen Activator Receptor

    Cat. No. Description Quantity Price
     CSI20008A Recombinant Mouse Soluble uPAR 100 µg $790

    VTN: Vitronectin

    Cat. No. Description Quantity Price
     CRV123B Native Human Monomeric Vitronectin 0.5 mg $1,200
     CRV124B Native Human Multimeric Vitronectin 100 µg $320
     CRV126B Native Human Multimeric Vitronectin, Biotinylated 100 µg $480

    Related Products

    Cat. No. Description Quantity Price
     CRA158B Native Human Alpha-2-Antiplasmin 1.0 mg $600
     CRG128B Native Human Glu Plasminogen 1.0 mg $250
  • Azide Free "B-clone" Monoclonal Antibodies

    B-Clone Antibodies to Cytokines, Chemokines and CD Antigens

    Investigate your cellular assay systems with Cell Sciences "B-clone" range of biologically active monoclonal antibodies. These antibodies contain no sodium azide and are suitable for induction, activation, neutralization and inhibition studies. These are highly specific, high quality antibodies for a broad range of proteins including human CD antigens, cytokines, cytokine/chemokine receptors, adhesion molecules and apoptosis related antigens.

    Cell Sciences B-Clone antibodies are useful for the investigation of innate and acquired immunity in many fields of research and are available for use in assay development.

    Anti-Human Monoclonal Antibodies:

    Specificity Clone Item # Biological Activity
    CD2 B-E2 CDM024 Inhibits mixed lymphocyte culture
    CD3 B-B11 CDM127 Induces T lymphocyte stimulation and proliferation
    CD4 B-A1 CDM130 Inhibits mixed lymphocyte culture
    CD10 B-E3 CDM143 Cytotoxic In association with rabbit complement on CD10+ cells
    CD20 B-H20 CDM160 Cytotoxic in association with complement on CD20 cells
    CD21 B-E5 CDM162 Induces human B-cell proliferation and competes with EBV for CD21 binding
    CD25 B-B10 CDM001 Inhibits mixed lymphocyte culture
    CD25 B-F2 CDM003 Inhibits mixed lymphocyte culture
    CD28 B-T3 CDM171 Inhibits mixed lymphocyte culture. Co-stimulates T-cell proliferation
    CD34 Class I B-G25 CDM175 Triggers KG-1a cell aggregation
    CD40 B-B20 CDM180 Stimulates B-cell proliferation together with IL-4
    CD44 Class I B-F24 CDM039 Triggers T-lymphocyte aggregation. Enhances Hyaluronan binding to CD44
    CD54 B-H17 CDM045 Inhibits PHA stimulated T-cell proliferation
    CD86 B-T7 CDM201 Inhibits mixed lymphocyte culture
    CD95 B-G27 CDM068 Triggers Fas induced apoptosis
    CD95 B-D29 CDM070 Inhibits FasL induced apoptosis
    CD102 B-T1 CDM051 Inhibits cell adhesion and T-cell activation
    CD106 B-K9 CDM054 Inhibits cell attachment to VCAM-1
    CD117 B-K15 CDM203 Inhibits the KIT ligand induced proliferation of TF1 cell line
    CD126 B-R6 CDM006 Inhibits IL-6 induced proliferation of XG-1 cells
    CD126 B-F19 CDM009 Inhibits IL-6 induced proliferation of XG-1 cell line. Inhibits IL-6 binding to its receptor
    CD130 B-R3 CDM012 Inhibits IL-6, IL-11, CNTF, LIF and OSM activities
    CD130 B-K5 CDM015 Inhibits CNTF activity. Inhibits OSM binding to gp130
    CD130 B-P8 CDM016 Inhibits CNTF activity and binding to gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation.
    CD130 B-P4 CDM017 Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities.
    CD130 B-S12 CDM019 Activates cells carrying gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation.
    CD178 B-R17 CDM073 Inhibits soluble CD178 induced apoptosis.
    CD184 B-R24 CDM219 Inhibits HIV-1 infection.
    CD202b B-B48 CDM229 Inhibits Tek-L / Tek binding.
    CD253 B-S23 CDM076 Enhances TRAIL induced apoptosis.
    CD253 B-T24 CDM080 Inhibits TRAIL induced apoptosis.
    CD261 B-N36 CDM231 Neutralizes TRAIL induced apoptosis on HEL cell line.
    CD262 B-K29 CDM234 Neutralizes TRAIL induced apoptosis of U937 cell line.
    CD262 B-D37 CDM237 Agonist: induced apoptosis on Jurkat cells. Enhances TRAIL induced apoptosis of U937 cell line.
    CD263 B-D44 CDM238 Inhibits TRAIL binding to TRAIL R3.
    CDw218a B-E43 CDM241 Inhibits human IFN-gamma secretion induced by IL-18 stimulated cells.
    CDw218b B-B46 CDM244 Inhibits human IFN-gamma secretion induced by IL-18 stimulated cells.
    IFN-g B-B1 CDM256 Inhibits IFN-gamma induced proliferation.
    IL-1 beta B-A15 CDM259 Inhibits IL-1 beta induced proliferation on D10S murine cell line.
    IL-2 B-G5 CDM261 Inhibits IL-2 induced proliferation on CTL-L2 murine cell line.
    IL-4 B-S4 CDM264 Inhibits IL-4 induced proliferation on TF1 cells.
    IL-6 B-E8 CDM265 Inhibits IL-6 induced proliferation on B9 cells.
    IL-8 B-K8 CDM268 Inhibits IL-8 induced chemotaxis of human neutrophils.
    IL-10 B-S10 CDM270 Inhibits IL-10 induced proliferation on MC/9 cell line.
    IL-12 p35+p70 B-T21 CDM271 Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes.
    IL-12 p40+p70 B-P24 CDM273 Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes.
    IL-13 B-B13 CDM275 Inhibits IL-13 induced proliferation on TF1 cell line.
    IL-15 B-E29 CDM282 Inhibits IL-15 induced proliferation on Kit 225 cell line.
    IL-17A B-B51 CDM114 Inhibits the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of defensin-2 production).
    IL-17F B-F60 CDM288 Neutralizes the bioactivity of IL-17F on HT1080 cell line (measurement of IL-6 production).
    IL-23 B-Z23 CDM115 Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production).
    NKp46 B-L46 CDM306 The biological activity is measured by the ability of the coated antibody to induce degranulation of activated NK cells and to enhance IFNγ secretion by non-activated NK cells.
    NTR 1 B-N6 CDM341 Inhibits neurotensin binding to its receptor.
    TNF-alpha B-C7 CDM276 Inhibits TNF-alpha induced cytotoxicity on U937 cells.
  • Fetal Bovine Serum, Premium Grade

    Cell Sciences Premium Grade FBS is a low endotoxin, low hemoglobin product for use in cell culture in a wide variety of applications. The FBS is collected and processed in the United States from fetuses of US origin cows. The product is single-sourced from one USDA approved facility with certified US origin animals only. The product is triple filtered using single-use filtration technology.

    Premium Grade FBS

    Features of Cell Sciences Premium Grade FBS:

    • Triple 0.1 µm sterile filtered.
    • ISIA certified raw material traceability.
    • Low Endotoxin <20 EU/ml.
    • CoA and CoO available.
    • Sample and reservation of lot available.

    Cell Sciences Premium Grade FBS is available in 50 ml and 500 ml size. Cell Sciences guarantees product quality and offers integrity and assurance of supply.

    Catalog No: CNF001A Fetal Bovine Serum, Premium Grade, 50 ml

    Catalog No: CNF001B Fetal Bovine Serum, Premium Grade, 500 ml

     

  • Bulk Cytokines with Custom Vialing

    20 - 50% off bulk cytokines, growth factors, chemokines and more...
    For a limited time Cell Sciences is offering substantial discounts on the following bulk size vials. These items are low endotoxin, carrier-free, highly pure, biologically active and suitable for cell culture and animal studies. Products include BMPs, Chemokines, Defensins, FGFs, GM-CSFs, Interferons, Interleukins, TNF-alpha, VEGF, and more. Species include human, mouse, rat, bovine and Rhesus macaque. Custom production and custom vialing to your specifications is available.

    Bulk Discount Recombinant Proteins:

    Cat. No. Description Quantity Price
    BAFF, Human
    1.0 mg
    $2,590 (30% off)
    BAFFR, Human
    1.0 mg
    $1,295 (20% off)
    BCMA/TNFRSF17, Human
    1.0 mg
    $2,590 (50% off)
    BMP-2, Human
    1.0 mg
    $2,295 (40% off)
    BMP-4 inactive, Human
    1.0 mg
    $1,640 (20% off)
    BMP-7, Human
    1.0 mg
    $1,690 (50% off)
    BNP/NPPB, Human
    1.0 mg
    $2,590 (50% off)
    CCL7, Human
    1.0 mg
    $1,640 (40% off)
    CCL14, Human
    1.0 mg
    $1,640 (40% off)
    CD40 Ligand, Human
    1.0 mg
    $790 (30% off)
    CNTF, Human
    1.0 mg
    $1,640 (40% off)
    CX3CL1, Human
    1.0 mg
    $1,640 (40% off)
    CXCL1, Human
    1.0 mg
    $1,640 (40% off)
    CXCL1/GRO alpha/KC, Rat
    1.0 mg
    $1,640 (40% off)
    CXCL2, Human
    1.0 mg
    $1,640 (40% off)
    CXCL3/MIP2-beta, Human
    1.0 mg
    $1,640 (40% off)
    CXCL5, Mouse
    1.0 mg
    $1,640 (40% off)
    CXCL9/MIG, Human
    1.0 mg
    $1,640 (40% off)
    CXCL10/IP10/CRG-2, Human
    1.0 mg
    $1,640 (40% off)
    CXCL11/I-TAC, Human
    1.0 mg
    $1,640 (40% off)
    CXCL12/SDF-1 alpha, Rat
    1.0 mg
    $1,640 (40% off)
    CXCL12/SDF-1 beta, Mouse
    1.0 mg
    $1,640 (40% off)
    CXCL13/BLC/BCA-1, Human
    1.0 mg
    $1,640 (40% off)
    CXCL16, Mouse
    1.0 mg
    $1,640 (40% off)
    Defensin beta 1 (47 aa), Human
    1.0 mg
    $1,640 (40% off)
    Defensin beta 2, Human
    1.0 mg
    $1,640 (40% off)
    Defensin beta 3, Human
    1.0 mg
    $1,640 (20% off)
    Defensin beta 4, Human
    1.0 mg
    $1,640 (40% off)
    ENA78, Human
    1.0 mg
    $1,640 (40% off)
    Eotaxin 2, Human
    1.0 mg
    $1,640 (40% off)
    Exodus-2, Human
    1.0 mg
    $1,640 (40% off)
    Exodus-2, Mouse
    1.0 mg
    $1,640 (40% off)
    FGF1/FGF-acidic (aa 141), Human
    1.0 mg
    $950 (30% off)
    FGF2/FGF-basic, Human
    1.0 mg
    $725 (30% off)
    FGF2/FGF-basic, Bovine
    1.0 mg
    $690 (30% off)
    FGF2/FGF-basic, Mouse
    1.0 mg
    $690 (40% off)
    FGF2/FGF basic, Rat
    1.0 mg
    $690 (30% off)
    FGF7/KGF-1, Human
    1.0 mg
    $2,590 (50% off)
    FGF7/KGF-1, Mouse
    1.0 mg
    $2,590 (30% off)
    FGF21, Human
    1.0 mg
    $1,640 (40% off)
    FLT3 Ligand, Human
    1.0 mg
    $2,170 (40% off)
    G-CSF/CSF3, Human
    1.0 mg
    $1,640 (50% off)
    GM-CSF/CSF2, Human
    1.0 mg
    $1,690 (40% off)
    GM-CSF/CSF2, Mouse
    1.0 mg
    $1,690 (40% off)
    IFN-alpha 2a, Human
    1.0 mg
    $375 (50% off)
    IFN-alpha 2b (E.coli), Human
    1.0 mg
    $375 (50% off)
    IFN-alpha 2b (Yeast), Human
    1.0 mg
    $690 (50% off)
    IFN-gamma, Human
    1.0 mg
    $690 (30% off)
    IFN-gamma, Mouse
    1.0 mg
    $690 (30% off)
    IFN-gamma, Rat
    1.0 mg
    $690 (30% off)
    IGFBP3, Human
    1.0 mg
    $1,640 (40% off)
    IL-1 alpha, Human
    1.0 mg
    $2,590 (50% off)
    IL-1 beta, Human
    1.0 mg
    $1,640 (50% off)
    IL-1RA/IL-1RN, Human
    1.0 mg
    $395 (50% off)
    IL-2, Human
    1.0 mg
    $395 (35% off)
    IL-2, Mouse
    1.0 mg
    $1,380 (50% off)
    IL-3, Human
    1.0 mg
    $1,640 (40% off)
    IL-3, Mouse
    1.0 mg
    $2,590 (50% off)
    IL-4, Human
    1.0 mg
    $1,930 (50% off)
    IL-4, Mouse
    1.0 mg
    $1,790 (50% off)
    IL-6, Human
    1.0 mg
    $1,640 (40% off)
    IL-6, Mouse
    1.0 mg
    $2,390 (50% off)
    IL-8/CXCL8 (72 aa), Human
    1.0 mg
    $1,640 (40% off)
    IL-8/CXCL8 (77 aa), Human
    1.0 mg
    $1,640 (40% off)
    IL-10, Human
    1.0 mg
    $2,590 (50% off)
    IL-10, Mouse
    1.0 mg
    $2,590 (50% off)
    IL-11, Human
    1.0 mg
    $2,590 (50% off)
    IL-11, Mouse
    1.0 mg
    $2,590 (50% off)
    IL-13, Human
    1.0 mg
    $2,895 (50% off)
    IL-13 Variant, Human
    1.0 mg
    $2,590 (50% off)
    IL-15, Human
    1.0 mg
    $1,790 (50% off)
    IL-17, Human
    1.0 mg
    $1,640 (40% off)
    IL-20, Human
    1.0 mg
    $2,590 (50% off)
    IL-21, Human
    1.0 mg
    $2,590 (50% off)
    IL-22, Human
    1.0 mg
    $2,590 (50% off)
    IL-29/IFN-lambda 1, Human
    1.0 mg
    $1,640 (40% off)
    IL-31, Human
    1.0 mg
    $2,590 (50% off)
    IL-33, Human
    1.0 mg
    $2,590 (50% off)
    IL-33, Mouse
    1.0 mg
    $2,590 (50% off)
    KGF-2/FGF-10, Human
    1.0 mg
    $1,890 (40% off)
    KIT Ligand/SCF, Human
    1.0 mg
    $1,790 (30% off)
    LEC, Human
    1.0 mg
    $1,640 (40% off)
    LIF, Mouse
    1.0 mg
    $1,640 (40% off)
    Lymphotactin/XCL1, Human
    1.0 mg
    $1,640 (40% off)
    MCP1, Human
    1.0 mg
    $1,640 (40% off)
    MCP2, Human
    1.0 mg
    $1,640 (40% off )
    MCP2, Mouse
    1.0 mg
    $1,640 (40% off )
    MCP-4/CCL13, Human
    1.0 mg
    $1,640 (40% off )
    M-CSF/CSF1, Human
    1.0 mg
    $2,590 (40% off )
    MDC/CCL22, Human
    1.0 mg
    $1,640 (40% off )
    MDC/CCL22, Mouse
    1.0 mg
    $1,640 (40% off )
    MEC/CCL28, Human
    1.0 mg
    $1,640 (40% off )
    MEC/CCL28, Mouse
    1.0 mg
    $1,640 (40% off )
    MIC-A, Human
    1.0 mg
    $1,640 (40% off )
    MIC-B, Human
    1.0 mg
    $1,640 (40% off )
    MIF, Human
    1.0 mg
    $1,640 (40% off )
    MIP-1 alpha/CCL3, Human
    1.0 mg
    $1,640 (40% off )
    MIP-1 beta, Human
    1.0 mg
    $1,790 (30% off )
    MIP-3, Human
    1.0 mg
    $1,640 (40% off )
    MIP-3 alpha/CCL20, Human
    1.0 mg
    $1,640 (40% off )
    MIP-4, Human
    1.0 mg
    $1,640 (40% off )
    MIP-5/CCL15, Human
    1.0 mg
    $1,640 (40% off )
    NAP-2/CXCL7, Human
    1.0 mg
    $1,640 (40% off )
    Noggin, Human
    1.0 mg
    $1,790 (50% off )
    Noggin, Mouse
    1.0 mg
    $1,790 (50% off )
    NRG1, Human
    1.0 mg
    $1,640 (20% off )
    Oncostatin M (aa 209), Human
    1.0 mg
    $2,590 (50% off )
    Oncostatin M/OSM, Human
    1.0 mg
    $2,590 (40% off )
    RANTES, Human
    1.0 mg
    $1,640 (40% off )
    SDF-1b/CXCL12, Rat
    1.0 mg
    $1,640 (40% off )
    Serpin F1/PEDF, Human
    1.0 mg
    $1,990 (50% off )
    SF20, Mouse
    1.0 mg
    $2,590 (50% off )
    Syndecan-4, Human
    1.0 mg
    $1,450 (50% off )
    TARC, Human
    1.0 mg
    $1,640 (40% off )
    TNF-alpha, Human
    1.0 mg
    $965 (30% off )
    TNF-alpha Variant, Human
    1.0 mg
    $1,190 (20% off )
    TNF-alpha, Mouse
    1.0 mg
    $1,390 (40% off )
    VEGF 165, Human
    1.0 mg
    $1,790 (50% off )
    VEGF 165, Mouse
    1.0 mg
    $1,790 (50% off )
    VEGF 120, Mouse
    1.0 mg
    $1,790 (50% off )
  • Products for Cell and Tissue Culture

    LRM001

    Human LR3 IGF1
    Human LR3 Insulin-like Growth Factor 1 (IGF1) is an 83 amino acid analog of human IGF1 comprising the complete human IGF1 sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Recombinant LR3 IGF1 has been developed specifically for supplementation of mammalian cell culture to support the survival and proliferation of cells. It is engineered to have a higher biological potency than native IGF1 or IGF2 and has several advantages over recombinant insulin, potency being among them. Published research has shown that supplementation of cell cultures with LR3 IGF1 at a much lower concentration results in equivalent or better productivity than supplementation with standard concentrations of insulin. LR3 IGF1 is better able to stimulate the Type I IGF Receptor and thus induce a higher level of activation of intracellular signaling molecules which are responsible for promoting cell survival by inhibition of apoptosis. A new formulation of this analog of IGF1 is lyophilized from a solution in PBS, allowing it to be directly dissolved in water or media.

    LRU100 Recombinant Human LR3 IGF1 100 µg 
    LRM001 Recombinant Human LR3 IGF1 1.0 mg 
    LRM010 Recombinant Human LR3 IGF1 10 mg

    Human Erythropoietin
    Erythropoietin (EPO) is a glycoprotein hormone that controls red blood cell production. It is a cytokine for erythrocyte precursors in the bone marrow. It is produced by the peritubular capillary endothelial cells in the kidney, and is the hormone that regulates red blood cell production. Recombinant Human Erythropoietin (EPO) is a glycosylated polypeptide chain containing 165 amino acids. It is a recombinant protein produced in mammalian cells for use in cell and tissue culture applications.

    CRE600A Recombinant Human EPO 500 IU 
    CRE600B Recombinant Human EPO 2000 IU 
    CRE600C Recombinant Human EPO 150k IU

    Bulk quantities of these products are available, please inquire.

  • Mouse MPO ELISA Kit

    Mouse MPO ELISA Kit
    1 x 96 tests
    Catalog Number CK210 Mouse MPO (Myeloperoxidase) ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse MPO in plasma and cell culture supernatants. This assay employs an antibody specific for mouse MPO coated on a 96-well plate. Standards and samples are pipetted into the wells and MPO present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-mouse MPO antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of MPO bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

    Included in the kit:

    • Microplate coated with Anti-Mouse MPO
    • Wash Buffer Concentrate (20x)
    • Recombinant Mouse MPO Standards
    • Assay Diluent C: Standard/Sample - Plasma Diluent Buffer
    • Assay Diluent B (5x): Standard/Sample - Cell Culture Medium Diluent
    • Detection Antibody: Anti-Mouse MPO Biotin
    • Streptavidin-HRP Concentrate (20,000x)
    • TMB One-Step Substrate Reagent (3, 3’, 5, 5’-tetramethylbenzidine in buffered solution)