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Anti-human Desmoglein-1, Clone 27B2, Monoclonal Antibody
| Catalog No: |
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HM2113
(datasheet)
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| Brand: |
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Hycult Biotechnology |
| Quantity: |
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100 µg |
| Price: |
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$420.00
add to cart
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| Category/Sub: |
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Monoclonal Antibodies / Adhesion Molecule Antibodies |
| Notes: |
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The antibody can be used for Western blotting, immunoprecipitation and immuno- fluorescence. Furthermore, the antibody is useful for immunohistology on frozen sections. The antibody does not inhibit the biological activity of desmoglein 1.
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| Isotype: |
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Mouse IgG1 |
| Description: |
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Desmoglein 1 is a member of the desmosomal cadherin family that comprises the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active, desmoglein 1 is essential to epidermal integrity. The antibody 27B2 reacts with the 165 kDa desmoglein 1 protein. Furthermore, it is not cross reactive with desmoglein 2 or desmoglein 3. |
| Applications: |
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IHC, FC, W, IP, IF |
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