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Anti-human Plakoglobin, Clone 15F11, Monoclonal Antibody
| Catalog No: |
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HM2116
(datasheet)
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| Brand: |
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Hycult Biotechnology |
| Quantity: |
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100 µg |
| Price: |
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$420.00
add to cart
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| Category/Sub: |
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Monoclonal Antibodies / Adhesion Molecule Antibodies |
| Notes: |
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The antibody can be used for Western blotting, immunoprecipitation and immunofluorescence with cells fixed in paraformaldehyde. |
| Isotype: |
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Mouse IgG1 |
| Description: |
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Plakoglobin, also known as gamma-catenin belongs together with alpha- and beta catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore, reduced plakoglobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas. Antibody 15F11 cross reacts with rat and weakly with mouse. |
| Applications: |
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W, IF, IP |
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