Mouse Anti-Bovine Prion Protein Clone 1E4 mAb

Molecule:

PRNP/PRPC

Synonyms:

PrP, major scrapie-associated fibril protein 1, prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia), prion protein PrP, prion protein precursor PrP

Species:

Bovine

Cat. No.:

M1839 pdf (datasheet)

Quantity/Size:

250 μl

Price:

$655.00 BUY

Concentration:

0.5 mg/ml

Description:

Background: A special feature of 1E4 is that its epitope is almost hidden on non-digested bovine PrPSc, but after Proteinase K digestion the epitope becomes available resulting in a significant increased detection.

Entrez Symbol:

PRNP

Uniprot Name:

Major prion protein

Uniprot ID:

P10279

Data PDF:

M1839

Specificity:

Bovine | The epitope recognized by 1E4 is amino acid 108-119 of the bovine prion protein sequence i.e. the N-terminal part of the protease K-resistant PrP27-30 fragment.

Host Species:

Mouse

Immunogen:

Bovine PrP108-119 sequence CGGQWNKPSKPKTN.

Isotype:

IgG1K

Clone:

1E4

Application notes:

Monoclonal antibody 1E4 is particularly suitable for immunohistochemical detection of prions characterized by a highly specific staining without any significant background as has been demonstrated for BSE in cattle and scrapie in sheep.