Mouse Anti-Human CD11b/CR3 Clone Bear-1 FITC mAb

Molecule:

CD11b | CR3

Synonyms:

CD11B , CR3A , MAC-1 , MAC1A , MO1A , SLEB6 , ITGAM , CR3

Species:

Human

Cat. No.:

MON1019F pdf (datasheet)

Quantity/Size:

0.5 ml

Price:

$245.00 BUY

Concentration:

100 tests / 0.5 ml

Description:

Mouse Anti-Human CD11b/CR3 Clone Bear-1 mAb MON1019 is an alpha chain integrin that is expressed as heterodimer noncovalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN extravasation to sites of inflammation. CD11b/CD18 interacts with both matrix and cell surface proteins including the complement component iC3b, extracellular matrix proteins and the third extracellular domain of CD54. CD11b is expressed on human NK-cells, monocytes, granulocytes, T-cells, B-cells and dendritic cells. After activation the expression is upregulated.

Entrez Symbol:

ITGAM

Data PDF:

MON1019F

Specificity:

CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer complex

Host Species:

Mouse

Isotype:

IgG1

Clone:

Bear-1 / VIM12

Conjugate:

FITC

Formulation:

0.5 ml antibody solution containing sodium-azide and a highly purified grade of BSA as a stabilizing protein. Final protein concentration is 4-5 mg/ml.

Purification:

Protein G

Application notes:

This antibody has been titrated for application in flow cytometry. Excitation 488 nm, Peak emission 525 nm. Based on testing it is recommended that 5 οΨΒg of antibody be used for 1 x 10E6 cells. Because results may vary, it is suggested that each investig

Storage/Stability:

Store at 2-8οΨΑC. NEVER STORE FROZEN. Fluorochrome conjugates should be stored in the dark. Avoid direct exposure to light durng handling and cell staining. Cells should be analyzed within 18 hours of staining.