Mouse Anti-Human CD11b/CR3 Clone Bear-1 mAb

Molecule:

CD11b | CR3

Synonyms:

CD11B , CR3A , MAC-1 , MAC1A , MO1A , SLEB6 , ITGAM , CR3

Species:

Human

Cat. No.:

MON1019-5 pdf (datasheet)

Quantity/Size:

5 ml

Price:

$885.00 BUY

Concentration:

100 οΨΒg/ml

Description:

Mouse Anti-Human CD11b/CR3 Clone Bear-1 mAb MON1019 is an alpha chain integrin that is expressed as heterodimer noncovalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN extravasation to sites of inflammation. CD11b/CD18 interacts with both matrix and cell surface proteins including the complement component iC3b, extracellular matrix proteins and the third extracellular domain of CD54. CD11b is expressed on human NK-cells, monocytes, granulocytes, T-cells, B-cells and dendritic cells. After activation the expression is upregulated.

Entrez Symbol:

ITGAM

Data PDF:

MON1019

Specificity:

CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer complex

Host Species:

Mouse

Isotype:

IgG1

Clone:

Bear-1 / VIM12

Formulation:

0.2 οΨΒm sterile filtered liquid solution in PBS + 0.02% Sodium Azide + 0.1% BSA.

Purification:

Protein G

Application notes:

For immunohistology and flow cytometry, dilutions to be used depend on detection system applied. The typical starting working dilution is 1:10. The antibody is not useful for immunohistology on paraffin sections.

Storage/Stability:

Store antibody at 2-4οΨΑC for up to 1 year.