Mouse Anti-Human CD41a Clone VM16a mAb

Molecule:

ITGA2B | CD41

Synonyms:

BDPLT16 , BDPLT2 , CD41 , CD41B , GP2B , GPIIb , GT , GTA , HPA3 , PPP1R93 , ITGA2B

Species:

Human

Cat. No.:

MON1144 pdf (datasheet)

Quantity/Size:

1 ml

Price:

$445.00 BUY

Concentration:

0.2 mg/ml

Description:

Mouse Anti-Human CD41a Clone VM16a monoclonal antibody recognizes the intact platelet GPIIb/IIIa complex (alphaIIb/beta3). It does not bind to dissociated GPIIb or GPIIIa. The antibody reacts with human platelets and megakaryocytes. The apparent molecular weight of GPIIIa, GPIIb alpha chain, and GPIIb beta chain under reducing conditions are as follows: GPIIIa: 110 kDa, GPIIb alpha chain: 125 kDa, GPIIb beta chain: 25 kDa. The antibody does not bind to platelets from patients with Glanzmann thrombasthenia and does not recognize the vitronectin receptor, which contains GPIIIa as a beta subunit. VM16a inhibits platelet Fc-receptor dependent reactions due to the proposed topographical association of the platelet Fc-receptor and the glycoprotein IIb-IIIa complex.

Entrez Symbol:

ITGA2B

Data PDF:

MON1144

Specificity:

Human CD41a (recognizes the intact platelet GPIIb/IIIa complex (alphaIIb/beta3))

Host Species:

Mouse

Isotype:

IgG1?

Clone:

VM16a

Formulation:

1 ml lyophilized purified IgG solution in PBS.

Purification:

Ammonium sulfate + DEAE-cellulose gradient elution

Application notes:

Marker for megakaryoblasts and megakaryoblastic leukemias. Functional studies. Indirect Immunofluorescence staining with analysis by cytofluorometry or fluorescence microscopy. Flow Cytometry.

Storage/Stability:

Store antibody at 2-8οΨΑC until expiration date.