Mouse Anti-Human CD42b / Platelet GPIbClone VM16d mAb

Molecule:

GP1B alpha

Synonyms:

BDPLT1 , BDPLT3 , BSS , CD42B , CD42b-alpha , DBPLT3 , GP1B , GPIbA , VWDP

Species:

Human

Cat. No.:

MON1146 pdf (datasheet)

Quantity/Size:

1 ml

Price:

$445.00 BUY

Concentration:

100 tests / 1 ml

Description:

Mouse Anti-human CD42b, Platelet GPIb Clone VM16d, monoclonal antibody is directed against the CD42b antigen, platelet glycoprotein GPIb, that serves as a receptor for von Willebrand factor and as a high affinity thrombin receptor. The antigen is expressed on human platelets and megakaryocytes. The antigen is absent or present in very low levels on platelets of patients with the Bernard-Soulier syndrome. VM16d inhibits low conc. thrombin (<0.1 U/ml) induced platelet aggregation and decreases thrombin binding to platelets. F(ab')2 and F(ab') fragments are equally effective as whole intact antibodies. The VM16d-epitope is located within the 45 kDa N-terminal domain of GPIb alpha- chain. VM16d does not effect platelet interaction with von Willebrand factor, leading to the conclusion that the antibody reacts with or nearby the thrombin receptor site.

Entrez Symbol:

GP1BA

Data PDF:

MON1146

Specificity:

Human CD42b

Host Species:

Mouse

Isotype:

IgG1?

Clone:

VM16d

Formulation:

1 ml lyophilized purified IgG solution in PBS with approximately 0.2 mg antibody/ml and sodium azide.

Purification:

Ammonium sulfate + DEAE-cellulose gradient elution

Application notes:

Analysis of platelet aggregation and detection of GPIb expression. The antibody is also useful for functional studies. The antibody is useful for indirect immunofluorescence staining with analysis by cytofluorometry or fluorescence microscopy.

Storage/Stability:

Store antibody at 2-8οΨΑC until expiration date.