Mouse Anti-Human CD45 Clone B-A11 FITC mAb

Molecule:

CD45

Synonyms:

LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180

Species:

Human

Cat. No.:

CDM372 pdf (datasheet)

Quantity/Size:

100 tests

Price:

$370.00 BUY

Concentration:

100 tests/ml

Description:

The mouse monoclonal antibody recognizes human CD45, a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. CD45 is a receptor type PTP, with an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. CD45 also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

Entrez Symbol:

PTPRC

Data PDF:

CDM372

Specificity:

Recognizes the Leucocyte Common Antigen (LCA) with different isoforms of 180-190 -205-220 kDa.

Host Species:

Mouse

Immunogen:

Thymus cells and Jurkat cell line.

Isotype:

IgG1

Clone:

B-A11

Conjugate:

FITC

Formulation:

Liquid in PBS + 5% BSA + 0.1 % sodium azide.

Application notes:

Flow Cytometry: Use 10 µl to label 106 cells or 100 µl of whole blood.

Storage/Stability:

Stable at 2-8°C for 1 year. For longer storage, freeze aliquots at -20 to -80°C.