Mouse Anti-Human CD45 Clone B-A11 mAb

Molecule:

CD45

Synonyms:

PTPRC, LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180

Species:

Human

Cat. No.:

CDM188 pdf (datasheet)

Quantity/Size:

200 tests

Price:

$275.00 BUY

Concentration:

100 tests/ml

Description:

The mouse monoclonal antibody recognizes human CD45, a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. CD45 is a receptor type PTP, with an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. CD45 also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

Entrez Symbol:

PTPRC

Uniprot Name:

Receptor-type tyrosine-protein phosphatase C

Uniprot ID:

P08575

Data PDF:

CDM188

Specificity:

Human | Recognizes Leucocyte Common Antigen (LCA) with different isoforms of 180-190-205-220 kDa

Host Species:

Mouse

Immunogen:

Thymus cells and Jurkat cell line

Isotype:

IgG1

Clone:

B-A11

Conjugate:

Unconjugated

Formulation:

Liquid in phosphate-buffered saline with 1 % BSA and 0.09 % sodium azide.

Purification:

Affinity chromatography

Application:

Application notes:

Flow Cytometry: Use 10 μl to label 1x10E6 cells or 100 μl of whole blood.

Storage/Stability:

Stable at +2-8°C for 12 months. For longer storage, freeze aliquots.