Mouse Anti-Human CD59 Clone MEM-43 FITC mAb

Species:

Human

Cat. No.:

CDM448 pdf (datasheet)

Quantity/Size:

100 tests

Price:

$450.00 BUY

Description:

The monoclonal antibody recognizes CD59, a cell surface glycoprotein that regulates complement-mediated cell lysis, and is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.

Entrez Symbol:

CD59

Data PDF:

CDM448

Specificity:

Reacts with a PI-linked glycoprotein, molecular weight 18-20 kDa, found in all types of leucocytes including platelets.

Host Species:

Mouse

Immunogen:

Thymocytes and T lymphocytes

Isotype:

IgG2a

Clone:

MEM-43

Conjugate:

FITC

Formulation:

Liquid in PBS + 5% BSA + 0.1% sodium azide.

Application:

IF

Application notes:

FC: 10 μl of conjugate to label 10e6 cells or 100 μl of whole blood.
IF/IHC: Tested for identification of CD59+ cells on cryostat sections of paroxysmal nocturnal haemoglobin urea type II & III cells.