Mouse Anti-Human IL-6ST Azide free Clone B-P4 mAb

Molecule:

IL-6ST

Synonyms:

IL-6 Signal Transducer, CD130, CDW130, GP130, IL-6RB

Species:

Human

Cat. No.:

CDM017 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$390.00 BUY

Concentration:

1 mg/ml

Description:

The monoclonal antibody recognizes human CD130, also known as Interleukin 6 Signal Transducer or gp130.

This antibody can be used as a Capture Antibody in a human CD130/IL-6ST sandwich immunoassay in combination with biotinylated anti-human CD130/IL-6ST Detection Antibody (CDM420).

Background: IL-6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL-6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). The protein functions as a part of the cytokine receptor complex and its activation is dependent upon the binding of cytokines to their receptors.

Entrez Symbol:

IL6ST

Uniprot Name:

Interleukin-6 receptor subunit beta

Uniprot ID:

P40189

Data PDF:

CDM017

Specificity:

Human | Recognizes the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.

Host Species:

Mouse

Immunogen:

Natural soluble gp130

Isotype:

IgG1

Clone:

B-P4

Conjugate:

Unconjugated

Formulation:

Sterile filtered (through a 0.22 μm filter) liquid in PBS without preservative and carrier.

Purification:

Ion exchange Chromatography

Application:

ELISA

Application notes:

Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities.
ELISA capture antibody: suggested coating concentration range is 0.5-5 µg/ml.

Storage/Stability:

Antibody solution is stable at 2-4°C for 1 year. Aliquot and freeze for longer storage.