Mouse Anti-Human IL-13 Azide free Clone B-B13 Blocking mAb

Molecule:

IL-13

Synonyms:

P600; IL-13

Species:

Human

Cat. No.:

CDM275 pdf (datasheet)

Quantity/Size:

500 μg

Price:

$540.00 BUY

Concentration:

1 mg/ml

Description:

Mouse Anti-Human IL-13 Clone B-B13 Azide Free mAb

This antibody can be used as a Capture Antibody in a human IL-13 sandwich immunoassay to detect human IL-13 in combination with biotinylated human IL-13 Detection Antibody (Cat No CDM431).

Background: Interleukin 13 (IL-13) is an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

Entrez Symbol:

IL13

Uniprot Name:

Interleukin-13

Uniprot ID:

P35225

Data PDF:

CDM275

Specificity:

Human | Recognizes both natural and recombinant IL-13

Host Species:

Mouse

Immunogen:

Recombinant human IL-13

Isotype:

IgG1

Clone:

B-B13

Conjugate:

Unconjugated

Formulation:

Liquid in phosphate-buffered saline. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free.

Purification:

Ion exchange Chromatography

Application:

ELISA

Application notes:

Blocks IL-13 induced proliferation on TF1 cell line.
Suitable for intra-cytoplasmic flow cytometry.
Detection Antibody ELISA: 0.5-2.5 µg/ml ELISPOT: 5-10 µg/ml

Storage/Stability:

Antibody solution is stable at 2-8°C for 1 year. Aliquot and freeze for longer storage.