Mouse Anti-Human Perforin Clone B-E48 Azide Free mAb

Molecule:

Perforin

Synonyms:

P1; PFP; FLH2; PFN1; HPLH2

Species:

Human

Cat. No.:

CDM090 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$390.00 BUY

Concentration:

1 mg/ml

Description:

Mouse Anti-Human Perforin Clone B-E48 Azide Free mAb

This antibody can be used as a Capture Antibody in a human Perforin sandwich immunoassay to detect human Perforin in combination with biotinylated human Perforin Detection Antibody (Cat No CDM438).

Background: Perforin 1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.

Entrez Symbol:

PRF1

Uniprot Name:

Perforin-1

Uniprot ID:

P14222

Data PDF:

CDM090

Specificity:

Human | Recognizes human Perforin, a 70 kDa protein

Host Species:

Mouse

Immunogen:

Natural human Perforin

Isotype:

IgG2b Kappa light chain

Clone:

B-E48

Conjugate:

Unconjugated

Formulation:

Liquid in phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free.

Purification:

Ion exchange chromatography

Application:

ELISA

Application notes:

ELISA / ELISPOT Capture Antibody:
ELISA: 0.5-2.5 µg/ml
ELISPOT: 5-10 µg/ml

Storage/Stability:

Stable at +2-8°C for 12 months. DO NOT FREEZE.