Native Human S100 Calcium Binding Protein B

Molecule:

S100B

Synonyms:

NEFοΨ†, S100οΨ†, S100-BοΨ†, S100beta

Species:

Human

Cat. No.:

CSI14709 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$670.00 BUY

Description:

S100 Calcium Binding Protein B (S100B) is an acidic calcium binding protein and a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

Entrez Symbol:

S100B

Data PDF:

CSI14709

Source:

Human Brain

Molecular Weight:

21.0 kDa

Physical State:

Lyophilized

Formulation:

Lyophilized from 5 mM Tris-HCl, pH 7.5 with 5 mM 2-mercaptoethanol and 5 mM EDTA.

Purity:

>98%

Reconstitution:

Centrifuge vial prior to opening. Reconstitute in 5 mM 2-Mercaptoethanol.

Storage/Stability:

Store at -20οΨΑC. Avoid repeated freeze-thaw cycles.

Application notes:

S100 protein is suitable for use as a standard in immunoassays and as an immunogen for antiserum production.