Rabbit Anti-Human MAP3K14/NIK pAb

Molecule:

NIK

Synonyms:

MAP3K14, mitogen-activated protein kinase kinase kinase 14, HS; NIK; HSNIK; FTDCR1B

Species:

Human

Cat. No.:

CPN000 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$260.00 BUY

Description:

Rabbit Anti-Human MAP3K14/NIK polyclonal antibody
Background: Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14), also known as NF-kappa B-Inducing Kinase (NIK), is a member of the MAP kinase kinase kinase family that binds TNF Receptor Associated Factor 2 (TRAF2) and stimulates NF-kappa B activity. NIK was initially isolated from a Human B cell cDNA library. NIK is a serine/threonine kinase and its kinase activity contributes to I-kappa B phosphorylation. The C-Terminal segment of NIK binds TRAF2. A mutant NIK with intact C-Terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kappa B activation. NIK also interacts with TNF Receptor Associated Factor 6 (TRAF6) and mediates IL1-induced NF-kappa B activation.

Entrez Symbol:

MAP3K14

Uniprot Name:

M3K14_HUMAN

Uniprot ID:

Q99558

Data PDF:

CPN000

Specificity:

Recognizes both natural and recombinant Human NIK

Host Species:

Rabbit

Immunogen:

E.coli-expressed Recombinant Human NIK fragment (aa 795-947)

Isotype:

IgG

Conjugate:

Unconjugated

Formulation:

Lyphilized from 1xPBS

Purification:

Protein A Chromatography

Reconstitution:

Centrifuge vial prior to opening. Add 200 μl of sterile, distilled water to the vial to fully solubilize the antibody to a concentration of 1 mg/ml.

Application:

WB

Application notes:

Western blot: working dilution of 1:2,000
Immunoprecipitation: working dilution of 1:500

Storage/Stability:

Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store desiccated at at -20°C for up to 1 year. After reconstitution, the preparation is stable for up to one month at 2-8°C. For long term storage, freeze in working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles.