Rabbit Anti-Human RGS3 pAb

Molecule:

RGS3

Synonyms:

RGS3, regulator of G-protein signaling 3, C2PA

Species:

Human

Cat. No.:

CPR100 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$280.00 BUY

Description:

This polyclonal antibody, which reacts with the RGS3 protein, was generated using E. Coli expressed human RGS3 (a.a. 401-519; corresponding to the C-terminal 119 residues) as an immunogen.
Background: RGS3 (regulator of G protein signaling 3) is a 519-residue protein that is widely expressed. The protein contains an RGS domain near the carboxy terminus that serve as a GTPase-activating protein (GAP). RGS3 negatively regulates the activation of Giα and Gαq. A truncated RGS3 (RGS3T), with its N-terminal 313 residues removed, has been shown to negatively regulate acenylyl cyclase and PLC. RGS3T may be localized in the nucleus and RGS3 is found in cytoplasm. Translocation to membrane is important for the RGS proteins to interact with heterotrimeric G proteins.

Entrez Symbol:

RGS3

Uniprot Name:

RGS3_HUMAN

Uniprot ID:

P49796

Data PDF:

CPR100

Specificity:

Recognizes both natural and recombinant Human RGS3

Host Species:

Rabbit

Immunogen:

E. Coli expressed human RGS3 (a.a. 401-519; corresponding to the C-terminal 119 residues)

Isotype:

IgG

Conjugate:

Unconjugated

Formulation:

Lyphilized from 1xPBS

Purification:

Protein A Chromatography

Reconstitution:

Centrifuge vial prior to opening. Add 200 μl of sterile, distilled water to the vial to fully solubilize the antibody to a concentration of 1 mg/ml.

Application:

WB

Application notes:

Western blot: working dilution of 1:5,000

Storage/Stability:

Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store desiccated at at -20°C for up to 1 year. After reconstitution, the preparation is stable for up to one month at 2-8°C. For long term storage, freeze in working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles.