Rabbit Anti-Human TLR4 pAb

Molecule:

TLR4

Synonyms:

TLR4, toll like receptor 4, TOLL, CD284, TLR-4, ARMD10

Species:

Human

Cat. No.:

CPT200 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$340.00 BUY

Description:

Rabbit Anti-Human Toll-Like Receptor 4 pAb
Background: Toll-Like Receptor 4 (TLR4) is a mammalian homologue of the Drosophila Toll protein. The Human TLR4 is a 799-residue type-1 transmembrane protein. The extracellular domain has leucine rich repeats and the intracellular domain is similar to that of the IL1 receptor. TLR4 is a receptor for LipoPolySaccharide (LPS). In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL1 receptor for signal transduction that leads to activation of NF-kappa-B.

Entrez Symbol:

TLR4

Uniprot Name:

TLR4_HUMAN

Uniprot ID:

O00206

Data PDF:

CPT200

Specificity:

Recognizes both natural and recombinant Human TLR4

Host Species:

Rabbit

Immunogen:

Recombinant human TLR4 (a.a. 6-169)

Isotype:

IgG

Conjugate:

Unconjugated

Formulation:

Lyphilized from 1xPBS

Purification:

Protein A Chromatography

Reconstitution:

Centrifuge vial prior to opening. Add 200 μl of sterile, distilled water to the vial to fully solubilize the antibody to a concentration of 1 mg/ml.

Application:

FC, WB

Application notes:

Western blot: 1:3,000
Flow cytometry: analysis of cell-surface expression of TLR4

Storage/Stability:

Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store desiccated at at -20°C for up to 1 year. After reconstitution, the preparation is stable for up to one month at 2-8°C. For long term storage, freeze in working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles.