Rabbit Anti-Rat TYROBP/DAP12 pAb

Molecule:

DAP12

Synonyms:

Tyrobp, Karap, DAP12, killer cell activating receptor-associated protein

Species:

Rat

Cat. No.:

CPD001 pdf (datasheet)

Quantity/Size:

200 μg

Price:

$280.00 BUY

Description:

Rabbit Anti-Rat TYROBP/DAP12/DNAX-activation protein 12 polyclonal antibody
Background: DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is a disulfide-bonded homodimer. Crosslinking of DAP12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.

Entrez Symbol:

Tyrobp

Uniprot Name:

TYOBP_RAT

Uniprot ID:

Q6X9T7

Data PDF:

CPD001

Specificity:

Recognizes both natural and recombinant rat TYROBP/DAP12

Host Species:

Rabbit

Immunogen:

Recombinant DAP12 peptide (amino acids 28-40)

Isotype:

IgG

Conjugate:

Unconjugated

Formulation:

Lyphilized from 1xPBS

Purification:

Protein A Chromatography

Reconstitution:

Centrifuge vial prior to opening. Add 200 μl of sterile, distilled water to the vial to fully solubilize the antibody to a concentration of 1 mg/ml.

Application:

WB

Application notes:

Western blot: 1:1,000

Storage/Stability:

Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store desiccated at at -20°C for up to 1 year. After reconstitution, the preparation is stable for up to one month at 2-8°C. For long term storage, freeze in working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles.