Rat Anti-Mouse IL-6 Clone MP5-32C11 mAb

Molecule:

IL-6

Synonyms:

Il-6 , IL6 , IL-6

Species:

Mouse

Cat. No.:

MON5017 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$740.00 BUY

Description:

The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of the bacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNF-alpha nor does it block human or rat IL-6 in proliferation assays using the KD83 cell line. MP5-32C11 inhibits mouse IL-6-induced proliferation of the NFS60 myelomonocytic cell line and KD83 plasmacytoma. IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe infection and regulates the immune response, acute phase reaction and hematopoiesis. IL-6 plays a critical role in Bcell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of antibody producing hybridomas.

Entrez Symbol:

IL6

Data PDF:

MON5017

Specificity:

Mouse IL-6

Host Species:

Rat

Isotype:

IgG2a

Clone:

MP5-32C11

Formulation:

Lyophilized product in PBS, containing 100 οΨΒg.

Reconstitution:

Reconstitute the vial by injection of 0.5 ml sterile distilled or de-ionized water (Caution: vial is under vacuum).

Application notes:

The antibody can be used for immunochemical investigations of mouse IL-6 in structural studies and for quantitative/qualitative immunochemical detection methods. The antibody neutralizes the biological activity of mouse IL-6. Furthermore the antibody is u

Storage/Stability:

Lyophilized product should be stored at 4οΨΑC. Store stock solution in aliquots at -20οΨΑC. Repeated freeze and thaw cycles will cause loss of activity. Under recommended storage conditions, product is stable for one year.