Recombinant Human Defensin beta 2 is a single non-glycosylated polypeptide chain containing 41 amino acids.
Background: Defensins (alpha and beta) are cationic peptides with antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses. They are 2-6 kDa proteins and take important roles in innate immune system. On the basis of their size and pattern of disulfide bonding, mammalian defensins are classified into alpha, beta and theta categories. ß-Defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Four human ß-defensins have been identified and they are expressed on some leukocytes and at epithelial surfaces. Because ß-defensins are cationic peptides, they can therefore interact with the membrane of invading microbes, which are negative due to lipopolysaccharides (LPS) and lipoteichoic acid (LTA) found in the cell membrane. Especially, they have higher affinity to the binding site compared to Ca2+ and Mg2+ ions. Furthermore, they can affect the stability of the membrane.
Toll Free 888-769-1246
All prices on this site are for orders shipping within the US and Canada.Prices are in US dollars.
These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.
All site content © 2017 Cell Sciences, Inc.