Recombinant Human Bone Morphogenetic Protein-4 is a monomeric, non-glycosylated, polypeptide chain containing 117 amino acids. This item is not biologically active. If you need a biologically active form of Recombinant Human BMP4, see Catalog Nos. CRB137A, CRB137B & CRB137C.
1. Molecular standard (Western, ELISA) in studying secreted BMP-4
2. Preparing antibodies for BMP-4 monomer
3. Molecule standard in detecting secreted BMP-4 in reduced SDS-PAGE
Background: Bone Morphogenetic Protein 4 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-4 is expressed in the lung and lower levels seen in the kidney. It also presents in normal and neoplastic prostate tissues, and prostate cancer cell lines. It regulates the formation of teeth, limbs and one from mesoderm. Furthermore it also plays a role in fracture repair. BMP-4 signals through tetrameric complexes composed of type I and type II receptors and regulates it function by interaction with multiple proteins and glycosaminoglycans. The human BMP-4 shares 98 % sequence indentity with mouse BMP-4. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.