Recombinant Human MIP-5/CCL15 is a single non-glycosylated polypeptide chain containing 92 amino acids.
Background: CCL15, a new human CC chemokine, was isolated from a human fetal spleen cDNA library. CCL15 cDNA encodes a predicted 113 amino acid (a.a.) protein containing a putative signal peptide of 21 (a.a.) that is cleaved to generate a 92 a.a. residue mature protein. Within the CC family members, human CCL15 shares 45%, 44%, 35%, and 30% a.a. homology with mouse C10, human MPIF-1, human HCC-1, and mouse MIP-1gamma, respectively. The gene for MIP-5 is found on chromosome 17 where the genes for most of the human CC chemokines are located. Human CCL15 is expressed in T and B lymphocytes, NK cells, monocytes and monocyte-derived dendritic cells. Human MIP-5 is chemotactic for T cells and monocytes and has been shown to induce calcium flux in human CCR-1-transfected cells.
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