Recombinant Human MIP-3/CCL23 is a single, non-glycosylated polypeptide chain containing 99 amino acids.
Background: Chemokine (C-C motif) Ligand 23/Macrophage Inflammatory Protein 3 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Alternative splicing of the MPIF1 gene results in two mRNAs that encode a short (CKbeta8) and a long (CKbeta81) isoform of the chemokine. CKbeta8 cDNA encodes a 120 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to generate a 99 aa residue mature CKbeta8 (aa 22 120). Additional N terminal processing of the 99 aa residue variant can generate a 75 aa residue CKbeta8 (aa 46 120) that is significantly more active than the 99 aa residue variant.
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