Recombinant Human Insulin-like Growth Factor-I Des(1-3) Receptor Grade

Molecule:

IGF-I

Synonyms:

IGF1 , IGF-I , IGFI , IGF-I , IGF1A

Species:

Human

Cat. No.:

DU020 pdf (datasheet)

Quantity/Size:

20 μg

Price:

$250.00 BUY

Description:

Human Des(1-3) Insulin-like Growth Factor-I (IGF-I) is a 67 amino acid analog of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu. Human Des(1-3) IGF-I is more potent than IGF-I in vitro and in vivo. This increased potency is due to reduced binding of human Des(1-3) IGF-I to most of the IGF binding proteins which normally inhibit the biological actions of IGF-I. Human Des(1-3) IGF-I binds to the Type 1 IGF receptor with similar affinity to full length IGF-I. This is a high quality reagent for use in studies on cell growth, IGF receptors and IGFBPs.

Entrez Symbol:

IGF1

Data PDF:

DU020

Source:

E. coli

Molecular Weight:

7.365 kD confirmed by Mass Spectrometry

Physical State:

Lyophilized

Formulation:

Lyophilized white powder dried from 0.1 M acetic acid and stored under dry nitrogen at a slight vacuum (-25 kPa).

Purity:

>95 % by HPLC and N-terminal sequence analysis

Biological Activity:

Stimulation of protein synthesis in rat L6 myoblasts: ED50 <10 ng/ml Type 1 IGF receptor binding assay: ED50 <10 ng/ml IGF binding protein assay: ED50 >100 ng/ml

Endotoxin Level:

<0.1 EU/οΨΒg

Reconstitution:

Use Protocol #1000 included with product

Storage/Stability:

Stable lyophilized for at least 2 years at 2-4οΨΑC