Recombinant Human Insulin-like Growth Factor-II Receptor Grade

Molecule:

IGF-II

Synonyms:

IGF-II , IGF2

Species:

Human

Cat. No.:

FM001 pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,130.00 BUY

Description:

Human Insulin-like Growth Factor-II (IGF-II) is a single chain 67 amino acid polypeptide that shares structural homology with insulin and human IGF-I. IGF-II plays a critical role in embryonic and foetal development via autocrine, paracrine and endocrine mechanisms. It is a mitogen and also has effects on cell migration and differentiation. IGF-II binds to the type I IGF receptor and the IGF-II/cation-independent mannose-6-phosphate receptor. Its actions are probably mediated through inducing signal transduction via one or both of these receptors. IGF-II also binds to each of the six IGF binding proteins (IGFBPs). This binding also regulates the biological function of IGF-II. IGF-II is highly conserved across species which suggests an important role for the peptide. Human IGF-II is present in high concentrations in normal adult human serum, although the function of this is unknown. IGF-II is also implicated in the pathophysiology of cancer, diabetes and obesity.

Entrez Symbol:

IGF2

Data PDF:

FU020

Source:

E. coli

Molecular Weight:

7469 daltons

Physical State:

Lyophilized

Formulation:

Lyophilized white powder dried from 0.1 M acetic acid and stored under nitrogen at a slight vacuum.

Purity:

>95% by HPLC

Biological Activity:

Proliferation of Chinese hamster ovary (CHO) cells (ED50 < 150 ng/ml) IGF type 1 receptor binding assay (ED50 < 20 ng/ml) IGF type 2 receptor binding assay (ED50 < 70 ng/ml) IGF binding protein assay (ED50 < 10 ng/ml)

Endotoxin Level:

<0.1 EU/οΨΒg

Reconstitution:

Protocol included

Storage/Stability:

Lyophilized protein is stable at 2-4οΨΑC for at least two years. Avoid repeated freeze-thaw cycles.