Recombinant Human Interferon alpha 2a

Molecule:

IFN-alpha 2a

Synonyms:

IFNA, INFA2, interferon alpha-2, leIF A, IFN-alpha-2, interferon alpha A, interferon alpha- A, alpha-2a interferon

Species:

Human

Cat. No.:

CRH063B pdf (datasheet)

Quantity/Size:

100 µg

Price:

$235.00 BUY

Description:

Interferon-alpha 2a (IFN-2a) is a type I interferon made by leukocytes during viral infection. The JAK-STAT pathway mediates the antiviral and anti-cell proliferation activities of IFN-2a. IFN- proteins are widely used as standard treatments during antiviral and antineoplastic therapies. The IFN-2a variant differs from IFN-2b by one amino acid.

Recombinant Human Interferon alpha 2a is a single non-glycosylated polypeptide chain containing 166 amino acids.

Entrez Symbol:

IFNA2

Data PDF:

CRH063

Source:

E. coli

Molecular Weight:

19.4 kDa

Formulation:

Lyophilized from a sterile-filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA).

Purity:

> 95% by SDS-PAGE

Biological Activity:

The protein has full biological activity when compared to the standard. The ED 50, is determined by dose-dependent viral CPE assay using EMC virus on A549 cells.

Specific Activity:

2.0 x 108 U/mg

Endotoxin Level:

1 EU/µg of protein by kinetic LAL analysis

Amino Acid Sequence:

MCDLPQTHSL GSRRTLMLLA QMRKISLFSC LKDRHDFGFP QEEFGNQFQK AETIPVLHEM IQQIFNLFST KDSSAAWDET LLDKFYTELY QQLNDLEACV IQGVGVTETP LMKEDSILAV RKYFQRITLY LKEKKYSPCA WEVVRAEIMR SFSLSTNLQE SLRSKE

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/ml. DO NOT VORTEX. Allow several minutes for complete reconstitution.

Storage/Stability:

Upon receipt, store desiccated at -20°C for up to 1 year. Upon reconstitution, the preparation is stable for up to one month at 2-8°C.