Recombinant Human NAP-2/CXCL7 is a single non-glycosylated polypeptide chain containing 70 amino acids.
Background: Neutrophil Activating Peptide 2 (NAP-2) is proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP) which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and to chemoattract and activate neutrophils. Although CTAP-III, beta-TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity.
Toll Free 888-769-1246
All prices on this site are for orders shipping within the US and Canada.Prices are in US dollars.
These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.
All site content © 2017 Cell Sciences, Inc.