Recombinant Human Neuregulin 1/Heregulin 1

Molecule:

NRG1/HRG1

Synonyms:

GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, MST131, MSTP131, pro-NRG1, glial growth factor, neu differentiation factor, neuregulin 1 type IV beta 3, neuregulin 1 type IV beta 1a, sensory and motor neuron derived factor, heregulin, alpha (45kD, ERBB2 p185-activator

Species:

Human

Cat. No.:

CRH005B pdf (datasheet)

Quantity/Size:

50 μg

Price:

$380.00 BUY

Description:

Background: Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene.

Entrez Symbol:

NRG1

Uniprot Name:

Pro-neuregulin-1, membrane-bound isoform

Uniprot ID:

Q02297

Data PDF:

CRH005

Genbank Accession No:

Q15491

Source:

E. coli

Molecular Weight:

7.5 kDa

Physical State:

Lyophilized

Formulation:

Lyophilized from a sterile filtered solution in 20 mM Phosphate buffer, pH 7.0 + 2% Mannitol containing carrier (0.5% HAS).

Purity:

>98% by SDS-PAGE and HPLC analyses.

Biological Activity:

ED50: <0.5 ng/ml (As determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells).

Specific Activity:

>2 x 10E6 U/mg

Endotoxin Level:

<0.1 ng/�g

Reconstitution:

Centrifuge vial prior to opening. Reconstitute in sterile ddH2O to a concentration of 0.1-1.0 mg/ml. The solution can then be further diluted in other aqueous buffers.

Storage/Stability:

Lyophilized protein is preferably stored desiccated at <0℃C. After reconstitution, stable for 1 week at 2-4℃C. For long term storage, aliquot and store at -20℃C. Avoid repeated freeze-thaw cycles.