Recombinant Human Oncostatin M is a single, non-glycosylated polypeptide chain containing 227 amino acids.
Background: Oncostatin M (OSM) is a member of the leukemia inhibitory factor/ oncostatin-M (LIF/OSM) family of proteins. OSM is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines and regulates the production of other cytokines, including IL-6, G-CSF and GM-CSF in endothelial cells. OSM is produced as a preproprotein and is proteolytically processed to generate the mature protein.
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