Recombinant Human PDGFRB (aa 558 - 1106) His

Molecule:

PDGFRB

Synonyms:

Platelet-Derived Growth Factor Receptor beta, CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT

Species:

Human

Cat. No.:

CSI13452 pdf (datasheet)

Quantity/Size:

10 μg

Price:

$595.00 BUY

Description:

Recombinant human PDGFR-beta contains the catalytic domain, amino acids 558-1106, with a 39 aa N-terminal addition including a 6x His tag.

Amino Acid Sequence

MSYYHHHHHH DYDIPTTENL YFQGAMLVPR GSPWDPEFQK KPRYEIRWKV IESVSSDGHE YIYVDPMQLP YDSTWELPRD QLVLGRTLGS GAFGQVVEAT AHGLSHSQAT MKVAVKMLKS TARSSEKQAL MSELKIMSHL GPHLNVVNLL GACTKGGPIY IITEYCRYGD LVDYLHRNKH TFLQHHSDKR RPPSAELYSN ALPVGLPLPS HVSLTGESDG GYMDMSKDES VDYVPMLDMK GDVKYADIES SNYMAPYDNY VPSAPERTCR ATLINESPVL SYMDLVGFSY QVANGMEFLA SKNCVHRDLA ARNVLICEGK LVKICDFGLA RDIMRDSNYI SKGSTFLPLK WMAPESIFNS LYTTLSDVWS FGILLWEIFT LGGTPYPELP MNEQFYNAIK RGYRMAQPAH ASDEIYEIMQ KCWEEKFEIR PPFSQLVLLL ERLLGEGYKK KYQQVDEEFL RSDHPAILRS QARLPGFHGL RSPLDTSSVL YTAVQPNEGD NDYIIPLPDP KPEVADEGPL EGSPSLASST LNEVNTSSTI SCDSPLEPQD EPEPEPQLEL QVEPEPELEQ LPDSGCPAPR AEAEDSFL

Background: PDGFR-beta is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The PDGF isoforms AA, BB, AB, CC, and DD are dimeric molecules. They bind two receptor molecules simultaneously and dimerize them upon binding. PDGFR-alpha binds the A, B, and C chains of PDGF with high affinity, whereas PDGFR-beta binds the B and D chain with high affinity.

Entrez Symbol:

PDGFRB

Data PDF:

CSI13452

Source:

Insect cells

Molecular Weight:

66.3 kDa (theoretical)

Formulation:

Liquid in 20 mM Tris, pH 7.5 + 100 mM NaCl + 0.05 mM EDTA + 0.05% NP-40 + 1 mM DTT + 50% glycerol.

Purity:

>85% by SDS-PAGE

Specific Activity:

200 nM of phosphate transferred to Abl1 peptide substrate (EAIYAAPFAKKK) per minute per mg of total protein at 30°C, at 5 µg/ml total protein concentration.

Storage/Stability:

Stable for 6 months at -80°C. DO NOT STORE DILUTED. Avoid repeated freeze-thaw cycles.