Recombinant Human RANTES/CCL5 is a single non-glycosylated polypeptide chain containing 68 amino acids.
Background: RANTES/CCL5 (acronym for Regulated upon Activation, Normal T cell Expressed and presumably Secreted), was initially discovered by subtractive hybridization as a transcript expressed in T cells but not B cells. Eosinophil chemotactic activities released by thrombin stimulated human platelets have also been purified and found to be identical to RANTES. Besides T cells and platelets, RANTES has been reported to be produced by renal tubular epithelium, synovial fibroblasts and selected tumor cells.
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