Recombinant Human Syndecan-4 is a single non-glycosylated polypeptide chain containing 127 amino acids.
Background: Syndecan-4 (SDC-4) also known as amphiglycan or ryudocan, is a member of the syndecan family of Type 1 transmembrane proteins capable of carrying heparan sulfate (HS) and chondroitin sulfate glycosaminoglycans. The four vertebrate syndecans have two conserved cytoplasmic domains and divergent extracellular portions, except for HS attachment sites. Syndecan4 is the most similar to Syndecan2, but is more universally expressed and is found in virtually every cell type. Expression can be upregulated by TGFβ2 and in response to mechanical stress in smooth muscle, wound healing, arterial injury or acute myocardial infarction, probably in response to at least one inflammatory mediator. Human Syndecan4 ECD shares approximately 79%, 78% and 81% aa identity with mouse, rat and porcine Syndecan4 ECD, respectively.
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