Recombinant Human TWEAK Receptor

Molecule:

TWEAKR

Synonyms:

FGF-inducible 14, fibroblast growth factor-inducible immediate-early response protein 14, tweak-receptor, type I transmembrane protein Fn14, FN14, CD266, TWEAKR

Species:

Human

Cat. No.:

CRT601C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$2,700.00 BUY

Description:

Recombinant Human TWEAK Receptor is a single non-glycosylated polypeptide chain containing 53 amino acids. Background: Human TNF-related weak inducer of apoptosis receptor (TWEAKR) also known as Tumor necrosis factor receptor superfamily member 12A precursor (gene name TNFRSF12A) or fibroblast growth factor-inducable 14 kD protein, is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. In addition, It plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis.

Entrez Symbol:

TNFRSF12A

Uniprot ID:

Q9NP84

Data PDF:

CRT601

Source:

E. coli

Molecular Weight:

~5.6 kDa

Physical State:

Lyophilized

Formulation:

Lyophilized from a 0.2 οΩΫm filtered concentrated solution in PBS, pH 7.4.

Purity:

>95% by SDS-PAGE and HPLC analyses.

Biological Activity:

Fully biologically active when compared to standard. The ED50 determined by inhibiting TWEAK dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30 ng/ml, corresponding to a specific activity of >3.3οΩΫ104 IU/mg, in the

Specific Activity:

>3.3 οΩΫ 10E4 IU/mg

Endotoxin Level:

<0.1 ng/οΩΫg of rHuTWEAKR as determined by LAL method

Amino Acid Sequence:

EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportio

Storage/Stability:

This lyophilized preparation is stable at 2-4οΩΫC, but should be kept desiccated at -20οΩΫC for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4οΩΫC. For maximal stability, apportion the reconstituted preparati