Recombinant Human soluble VEGFR-1 D1-5

Molecule:

VEGFR1/FLT1

Synonyms:

VEGFR-1, fms-like tyrosine kinase 1, tyrosine-protein kinase FRT, tyrosine-protein kinase receptor FLT, vascular permeability factor receptor, FLT, VEGFR1

Species:

Human

Cat. No.:

CRF102C pdf (datasheet)

Quantity/Size:

1.0 mg

Description:

Background: Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression

Entrez Symbol:

FLT1

Uniprot Name:

Vascular endothelial growth factor receptor 1

Uniprot ID:

P17948

EC number:

2.7.10.1

Data PDF:

CRF102

Source:

Insect cells

Molecular Weight:

70.0 kDa

Physical State:

Lyophilized

Formulation:

Lyophilized from a sterile filtered solution in PBS.

Purity:

>90% by SDS-PAGE analysis.

Biological Activity:

ED50: Typically 10-25 ng/ml (Determined by its ability to abolish the binding of iodinated VEGF to solid surfaces or cell surfaces receptors. In a 13 day CAM-assay sVEGFR-1 is able to inhibit VEGF stimulated sprouting of capillaries at 30 pM).

Endotoxin Level:

<0.1 ng/�g

Reconstitution:

Centrifuge vial prior to opening. Reconstitute in sterile ddH2O to a concentration of ?100 ng/ml. The solution can then be further diluted in other aqueous buffers.

Storage/Stability:

Lyophilized protein is stable at 2-4℃C for 2 days and at -20℃C to -80℃C for >6 months. Avoid repeated freeze-thaw cycles.