Recombinant mouse multimeric CD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of mouse ACRP30 (adiponectin). This construct effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to using a combination of CD40L plus an enhancer to increase efficacy. Multimeric CD40L has been shown to suppress alum-induced IL-1β release and caspase-1 activation in a CD40-, dose-, and time-dependent manner without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
Mouse CD40L, aa 115-260, is fused at the N-terminus to mouse collagen domain of ACRP30 (aa18-111) and a FLAG tag.
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