Human Angiostatin ELISA Kit

Molecule:

Angiostatin

Species:

Human

Cat. No.:

CKH119 pdf (datasheet)

Quantity/Size:

1 Plate

Price:

$695.00 BUY

Description:

Angiostatin was observed initially as an angiogenesis inhibitor in serum and urine of mice bearing a Lewis lung carcinoma (3LL cells). Angiostatin is produced by the protelytic cleavage of plasminogen by a serine protease from several human prostate carcinoma cell lines. The production of Angiostatin by human pancreatic cancer cells can be inhibited by TGF-beta-1 in participation with plasminogen activator inhibitor type-1. Angiostatin specifically inhibits endothelial cell proliferation. In an animal tumor model the factor produced by the primary tumor suppresses the growth of its remote metastases, which neovascularize and grow after tumor removal.

Sensitivity:           20 ng/ml

Range:                 20 - 2000 ng/ml

Cross-reactivity:   no cross-reactivity with any of the cytokines tested (human Angiopoietin-1, B7-1, BMP-7, CD14, CD30, CD40, CD40 Ligand, CTLA-4, CXCL16, Dkk-4, DR6, Endostatin, E-Selectin, Follistatin, HB-EGF, HVEM, ICAM-2, IGF-II, IL-10 Ra, IL-10 Rb, IL-18, IL-9 , IL-2 Ra, IL-2 Rb, IL-5 Ra, LAP, LSelectin, M-CSFR, MMP-2, 3, 7, 8, 9, 10 and 12, PDGF-AB, SDF-1b, Tie-1, Tie-2, TIMP-3).

Entrez Symbol:

PLG

Uniprot Name:

Angiostatin

Uniprot ID:

P00747

Kit Plates:

Precoated stripwell plates

Storage/Stability:

Store all reagents at 2-8°C or -20°C. Avoid freeze thaw cycles.