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The Human anti-adalimumab ELISA is an enzyme linked immunoassay (ELISA) for fast, reproducible and specific semi-quantitative determination of antibodies against adalimumab in human plasma and serum samples. Together with the measurement of adalimumab drug levels, the anti-adalimumab antibody measurement is important for patient adjusted treatment schedules. Low drug levels are frequently an indication for antibody formation against adalimumab.
In approximately 25 to 30% of the rheumatoid arthritis patients treated with adalimumab, antibodies are formed directed towards the idiotype of adalimumab. This can hamper the function of the TNF inhibitor and can cause a reduction in plasma concentration of the TNF inhibitor.
FOR RESEARCH ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.