Human Anti-SARS-CoV-2 (2019-nCoV) RBD, Clone REGN10987, mAb

Synonyms:

Spike glycoprotein, S glycoprotein receptor binding domain, S-RBD

Species:

SARS-CoV-2

Cat. No.:

CPC512B pdf (datasheet)

Quantity/Size:

100 µg

Price:

$490.00 BUY

Concentration:

1.0 mg/ml

Description:

Recombinant Human anti-SARS-CoV-2 Spike Protein Receptor Binding Domain, Clone REGN10987, is expressed in XtenCHO.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID -19). The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The spike glycoprotein is found on the outside of the virus particle and gives coronavirus viruses their crown-like appearance. Spike glycoprotein is cleaved into the following 3 chains, Spike protein S1, Spike protein S2, Spike protein S2'. Spike protein S1 attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Surface glycoprotein is an important target for vaccine development, antibody therapies and diagnostic antigen-based tests.

Uniprot Name:

Spike glycoprotein

Uniprot ID:

P0DTC2

Specificity:

Recognizes SARS-CoV-2 Spike-RBD protein

Host Species:

Human

Immunogen:

Recombinant SARS-CoV-2 Spike-RBD protein

Isotype:

IgG

Clone:

REGN10987

Formulation:

Sterile-filtered PBS, pH 7.5 preservative free.

Purification:

Protein A affinity chromatography

Application:

ELISA, WB

Application notes:

ELISA: suggested dilution 1:5,000 - 1:10,000
Western blot: suggested dilution 1:1,000 - 1:2,000

Storage/Stability:

Stable at 2-8°C for 1 week or for up to 1 year at -20°C to -80°C. It is recommended to prepare working aliquots of undiluted product and store -20°C to -80°C.