Human Cannabinoid 1 Receptor

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CSH1036PR pdf (datasheet)


50 µg


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The cannabinoid type 1 receptor is a G protein-coupled receptor located in the central and peripheral nervous system. It is activated by the endocannabinoid neurotransmitters anandamide and 2-arachidonoylglycerol and by plant and synthetic cannabinoids, including the principle psychoactive constituent of marijuana - THC (tetrahydrocannabinol). Upon activation, CNR1 receptor exhibits its effects mainly through activation of Gi, which decreases intracellular cAMP concentration by inhibiting its production enzyme, adenylate cyclase, and increases mitogen-activated protein kinase (MAP kinase) concentration.

The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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