Human D(1B) dopamine receptor


D(5) dopamine Receptor, D1beta dopamine receptor, Dopamine D5 receptor, DRD1L2, DRD1B, DBDR

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CSH1110PR pdf (datasheet)


50 µg


$8,780.00 BUY


DRD5 encodes the G-protein coupled receptor D(1B) dopamine receptor, also known as D1BR. The D5 receptor is highly homologous to the D1 receptor. The D5 receptor is expressed in neurons in the limbic regions of the brain, and has a 10-fold higher affinity for dopamine than the D1 subtype. Both D5 and D1 subtypes activate adenylyl cyclase. D1 receptors were shown to stimulate monophasic dose-dependent accumulation of cAMP in response to dopamine, and the D5 receptors were able to stimulate biphasic accumulation of cAMP under the same conditions, suggesting that D5 receptors may use a different system of secondary messengers than D1 receptors. D1 and D5 receptors are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes D1 and D5 are highly homologous and very few ligands are selective between them. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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