Human Frizzled-2


Frizzled Class Receptor 2, Fz2, FzE2, hFz2, Frizzled 2 Seven Transmembrane Spanning Receptor, Frizzled Family Receptor 2

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CSH3136PR pdf (datasheet)


50 µg


$8,780.00 BUY


FZD2 encodes the G protein-coupled receptor for Frizzled-2, a receptor for Wnt signaling proteins. Most of the frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK -3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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