Human Frizzled-7

Synonyms:

Frizzled Class Receptor 7, Fz-7, hFz7, FzE3, Frizzled 7 Seven Transmembrane Spanning Receptor

Cat. No.:

CSH3119MP pdf (datasheet)

Quantity/Size:

10 mg

Price:

$1,695.00 BUY

Description:

FZD7 encodes the G protein-coupled receptor for Frizzled-7, a receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance betacatenin-mediated signals in poorly differentiated human esophageal carcinomas. Most of the frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

Uniprot ID:

O75084

Data PDF:

CSH3119