Human G-protein coupled estrogen receptor 1


Chemoattractant receptor-like 2, CMKRL2, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, G-protein coupled receptor 30, GPCR-Br, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, LYGPR, Membrane estrogen receptor, MER, Constitutively Expressed Peptide-Like Receptor, Heptahelix Receptor, LERGU2

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CSH3097PR pdf (datasheet)


50 µg


$8,780.00 BUY


GPER1 encodes a multi-pass membrane protein known as G-protein coupled estrogen receptor 1, a member of the G-protein coupled receptor 1 family. Localized in the endoplasmic reticulum, this receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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