Human G-protein coupled receptor 35


G Protein-Coupled Receptor 35, Kynurenic Acid Receptor, KYNA Receptor

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CSH3031PR pdf (datasheet)


50 µg


$8,780.00 BUY


GPR35 encodes the G-protein coupled receptor 35. It is still considered an orphan receptor, but there have been attempts to deorphanize it by identifying endogenous molecules that can activate the receptor. It has been reported to act as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn. An important paralog of this gene is GPR55. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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