Human Hydroxycarboxylic acid receptor 2


G-Protein Coupled Receptor 109A, GPR109A, G-Protein Coupled Receptor HM74A, HM74a, Niacin Receptor 1, Nicotinic Acid Receptor, Hydroxy-Carboxylic Acid Receptor 2, HCA2, Puma-G, HM74b

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CSH3070PR pdf (datasheet)


50 µg


$8,780.00 BUY


HCAR2 encodes the protein known as Hydroxycarboxylic acid receptor 2, also known as niacin receptor 1 (NIACR1) and GPR109A. This receptor is a high-affinity Gi/Go-coupled G protein-coupled receptor (GPCR) for nicotinic acid (niacin) and is a member of the nicotinic acid receptor family of GPCRs. It mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified receptor in HEK293 or CHO. Various tagged versions are available.

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